This study aimed to encapsulate Celastrus paniculatus seed oil (CPSO) in 2-hydroxypropyl ..-cyclodextrin ..... cavities and investigate their biological activity, physicochemical stability,\nand skin penetration by vertical Franz diffusion cells of the CPSO-HP ... inclusion complex\nformulations. For biological activity studiesâ??including 2,2-diphenyl-1-picryhydrazyl radical (DPPH)\nscavenging, metal ion chelating, and inhibition of lipid and tyrosinase inhibition activitiesâ??the\nCPSO-HP .... inclusion complex exhibited lower inhibition activity than free CPSO. CPSO-HP ... dispersion, serum, and gel formulations were prepared. All formulations containing the\nCPSO ... inclusion complex showed no significant changes in physical characteristics after three\nmonthsâ?? storage. The percentages of oleic acid remaining in all formulations were over 80% of the\ninitial amount during a three-month stability study. For the skin-penetration study, compared to other\nformulations, the CPSO-HP ... serum formulation exhibited the highest cumulative amount of oleic\nacid in the whole skin and flux through receptor fluid, after six hours, of 32.75 ± 1.25 ...... and ..... respectively. The CPSO-HP .... serum formulation also showed the proper\nviscosity. Hence, the CPSO-HP .... inclusion complex will be beneficial for the further development\nof cosmeceutical products.
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